Skip to main content

吉林11遗漏一定牛:Solubility Enhancement and Emulsion Formulation

安徽快三开奖员 www.h8iz.cn SEPPIC adresses formulator issues with solubilizers and emulsifiers

Drug formulators often face API (Active Pharmaceutical Ingredient) bioavailability issues
Solubility is one of the key factors. A rising number of therapeutic drugs currently in preclinical and clinical developments are poorly water soluble. This number is estimated at 40-70% of NCEs (New Chemical Entities (NCEs)).

Once administered, a drug must be in a solution form to be absorbed regardless of the route of administration.

Developing pharmaceutical formulations with appropriate solubility will be one of the key challenges of next years.

When solution is not the optimal option to deliver the API or when drug formulators want to develop a modified release system, they might go through emulsion vehicles thanks to use of emulsifiers.

Emulsifiers and solubilizers offered by SEPPIC enable drug formulators to manage their challenges with poorly water soluble APIs.

Solubilization

Whatever the route of administration of a drug, the formulator might have the need of a solubilizer from SEPPIC to achieve optimal solubilization.
The target is to achieve a concentrated, clear, homogenous and stable solution in order to deliver the API in an efficient way.

SEPPIC offers different ranges of solubilizers under:

  • ?MONTANOX? range: Polysorbates
  • ?SEPITRAP? range: Solubilizers in powder form for direct compression
  • ?SEPICLEAR? : The SEPPIC novel excipient
  • ?SIMULSOL?: Fatty acids, fatty alcohols and castor oil derivatives


The choice of solubilizers is mainly driven by route of administration and nature of the API.

Emulsion

Drugs may be formulated with an emulsion as a vehicle to improve its bioavailability (sustained release, lipophilic or hydrophilic API solubilization, permeability...) or treatment compliance (texture).
An emulsion is a system made of at least two phases. It should be homogeneous and stable, thanks to addition of one or several emulsifiers.
Emulsifiers are used in pharmaceutical formulations to get stable emulsions to achieve the physico-chemical characteristics required for optimal delivery of API.

Depending on the emulsion type - Water in oil (W/O) or Oil in water (O/W) - emulsifiers are selected depending on their lipophilic/hydrophilic nature. They can be characterized thanks to their HLB (Hydrophilic/Lipophilic Balance) value.

SEPPIC offers different ranges of emulsifiers:

  • ?MONTANE? range: sorbitan esters
  • ?MONTANOX? range: polysorbates
  • ?SIMULSOL? range: ethoxylated fatty acids, fatty alcohols and castor oils
  • ?SIMALINE WO? : PEG 30 Dipolyhydroxystearate


Some emulsifiers may also have other functions depending on their HLB value: anti-foaming, wetting, foaming or solubilising functions.
?

  • 【永定门奥迪中心车型报价】永定门奥迪中心4S店车型价格 2019-06-18
  • 相信我:那将要到来的不是爱,而是美 2019-06-18
  • 楚天传媒大厦招租信息 2019-06-17
  • 全年龄段探索 国产动画正在“长大” 2019-06-14
  • 英国家长也在为孩子升学操心 2019-06-12
  • 新简明中共党史辞典(1921 2019-05-23
  • 广州市荔湾区人民法院公告专栏 2019-05-07
  • 现场!成都闹市一越野车逆向冲撞人群  嫌疑人已被警方刑拘 2019-04-30
  • 北京市北京龙腾信达综合店【在线咨询】 2019-04-30
  • 逆天跨界!RIO花露水风味鸡尾酒现象级刷屏 2019-04-24
  • 招商局集团副总经理王宏一行到访省投资集团 2019-04-17
  • 从稳中向好发展态势看我国经济良好前景 2019-04-17
  • 【理上网来·辉煌十九大】习近平新时代中国特色社会主义经济思想对中国经济学理论的贡献 2019-04-11
  • 不断变化包括不断转换套路。拳击不是你的强项就可来散打等你的强项嘛,实在不行就使拌子。 2019-03-31
  • 真正聪明的人,总有办法把自己整哭 2019-03-24
  • 184| 440| 557| 783| 640| 37| 994| 761| 229| 531|